Technology
CORE TECH
Nanopore Sequencing Principle
Nanopores generally refer to pore structures with a diameter of 1-10 nm. Nanopores can be embedded in phospholipid membranes through self-assembly to form transmembrane channels. When voltage is applied across the nanopore, negatively charged nucleic acid molecules in the sample are driven by electrophoresis to pass through the nanopore, generating specific current signals. By analyzing the temporal characteristics of these signals, the nucleotide sequence can be resolved, achieving DNA sequencing.
Advantages
Long Read Length
Read length is unlimited, depending on the sample fragment length. It can display complete gene sequences, facilitating detection of repetitive sequences and structural variations.
Low Cost
Separation from the signal acquisition chip significantly reduces the single-use cost of consumables.
Real-time
Sequence results are output in real-time without long waits.
Portable
Significantly smaller than NGS devices, enabling sequencing anywhere, anytime.
Rapid
Simple library prep and ability to stop sequencing anytime, greatly compressing turnaround time.
Direct Detection
No PCR amplification required; direct sequencing of epigenetic modifications and RNA.
Applications
Tumor Companion Diagnosis
Determining drug receptor sites via sequencing to guide targeted therapy.
Genetic Disease Diagnosis
Long-read sequencing excels at detecting mutations in large genomic fragments, enabling tailored treatment plans.
Environmental Monitoring
Amplicon sequencing, metagenomics, and WGS for environmental microbial detection.
Pathogen Detection
4-6x faster than traditional methods. Detects bacteria, viruses, and fungi in 4-6 hours with high sensitivity for 20,000+ pathogens, including AMR and virulence factors.
Forensic Identification
Gene sequencing results provide strong, irrefutable evidence for criminal investigations.
Agro-Food Safety
Label-free and portable detection of heavy metals, biotoxins, antibiotics, pesticides, and illegal additives.